Sentinel node biopsy malignant melanoma serial#

After 5 min, planar images of antero-posterior projections of the groin, abdomen and arms were obtained. Lymph gammagraphy analysis was conducted with 1.5 mCi of 99 m Tc-albumin nanocolloid by perilesional injection on the day of surgery.

Sentinel node biopsy malignant melanoma serial#

The pathological study protocol included deferred SLNB, 4 μ serial sections 4 cuts were made at each level: 2 for hematoxylin-eosin (HE) stain, and 2 for S-100 protein and HMB-45 immunohistochemistry (IHC), until exhausting the sample. Lymphadenectomy was performed subsequently on patients with SLN metastasis. All cases were included for SLNB after being discussed in a multidisciplinary committee. Lymph node involvement was ruled out by examination and if in doubt, histological analysis after puncture. 3 Other authors advocate including patients with a thickness 75% or incomplete excision with deep affected margin), Ib, IIa, IIb and IIc (in good general condition). Patients with melanoma less than 0.75 mm have a 1% risk of lymph node involvement, and it is not recommended for them.

5 It is prescribed for patients with localized disease (stages I– II). SLNB provides important information for tumor staging to detect micro-metastases. 2,4 It is a minimally invasive method to identify patients with occult lymph node metastasis and avoid lymphadenectomy in a large number of patients without lymph node involvement. Therefore, a first nodal drainage station sentinel lymph node (SLN) examination would safely reflect the status of the remaining regional lymph nodes. The procedure is based on the hypothesis that lymphatic metastases follow an orderly, sequential and non-random progression. published the first paper on using sentinel lymph node biopsy (SLNB) for melanoma. Given that it affects young people with significant mortality rates, it is a worldwide public health problem. The incidence of melanoma has increased rapidly in recent years. El único factor predictor de resultado positivo del GC fue el espesor tumoral. El melanoma de tronco fue la principal localización de drenaje múltiple. La BGC seleccionó de forma adecuada a los candidatos a linfadenectomía. El estudio definitivo de la BGC fue positivo en 18 casos (7,1%), siendo el factor predictivo relacionado el espesor tumoral (p = 0,01). El número de ganglios aislados fue entre 1 y 6, siendo en 98 casos (78,4%) de localización única y en 27 (21,6%) múltiple, de los que 25 (92,6%) se localizaron en el tronco. La mediana del índice de Breslow fue de 1,81 (0,45-5). La distribución anatómica de los ganglios centinelas (GC) fue: 44 (35,2%) en miembros inferiores, 24 (19,2%) en miembros superiores, 53 (42,4%) en tronco y 3 (2,4%) en cabeza y cuello. Se incluyó a 125 pacientes con una media de edad de 55,6 (± 15) años. Material y métodosĮstudio retrospectivo y analítico de aquellos pacientes a los que se les realizó BGC por melanoma, en el período entre agosto de 2000 y febrero de 2013. The only predictive factor of positive SNB was Breslow thickness.Įl objetivo del estudio es analizar nuestra experiencia en el uso de la biopsia del ganglio centinela (BGC) en el melanoma y determinar la existencia de factores predictores de resultado positivo y de drenaje múltiple. Melanoma of the trunk was the principal location of multiple drainage predictors. The SNB allows patients to be selected for lymphadenectomy. Breslow thickness ( P=.01) was statistically significant predictor of a positive SNB. The definitive result of sentinel node (SN) was positive in 18 cases (7.1%). The trunk was the localization of 25 (92.6%) nodes with multiple drainage. The drainage was unique in 98 (78.4%) and multiple in 27 (21.6%).

The median Breslow index was 1.81 (0.45–5). SNB was performed in 125 patients with a median of age of 55.6 (± 15) years. Retrospective study of patients who underwent SNB for melanoma between August of 2000 and February of 2013. The objective of this study is to analyze our experience in the use of sentinel node biopsy (SNB) in melanoma and identify the predictive factors of positive SNB and multiple drainage.